Preclinical r&d services

  • Our innovative R&D solutions (InnoRD™) reduce the time of your development as we develop the best preclinical models for your needs.
  • Complex animal models of cardiovascular (e.g. infarction, heart failure, stroke) and metabolic diseases (e.g. diabetes, hyperlipidemia, atherosclerosis, obesity, aging) for proof-of-concept studies.
  • We design custom models for your needs.
  • Special risk sharing opportunities available.
  • Cardiovascular Platform: Cardiovascular Technology platform for preclinical R&D is under continuous development.
  • Metabolic Platform: Metabolic Technology platform for preclinical contract research is under continuous development.
  • Large Animal Models: We provide large animal models for different indication

EXAMPLES OF OUR RESEARCH SERVICES IN COMPLEX IN VIVO AND EX VIVO MODELS OF VARIOUS DISEASES, ASK FOR FURTHER DETAILS:

  • Testing cardioprotective compounds on acute and chronic coronary occlusion-induced myocardial ischemia/reperfusion, myocardial infarction, preconditioning, and postconditioning.
  • Testing compounds for heart failure induced by chronic coronary occlusion-induced infarction, isoproterenol, or cardiotoxic agents such as doxorubicin.
  • Testing cardioprotective compounds in organ storage models
  • Testing vascular functions in hyperlipidemia/atherosclerosis and nitrate-tolerance models.
  • Evaluation of antidiabetic compounds in type 1 and type 2 diabetic models (STZ, Goto-Kakizaki, Zucker Diabetic Fatty, etc).
  • Evaluation of compounds acting on the nitric oxide-cGMP system and peroxynitrite formation, e.g. peroxynitrite scavengers.
  • Testing antiplatelet compounds in platelet aggregation systems
  • Testing antioxidant agents in cardiovascular and metabolic disease models
  • Evaluation of cardiac heat-shock protein (HSP) inducers. Evaluation of matrix metalloproteinase (MMP) inhibitors. many more…

For further details on our innovative precilinical (nonclinical) services, please do not hesitate to contact us at businessdevelopment@pharmahungary.com