Cardiac electrophysiology

Cardiac electrophysiology models for preclinical R&D are under continuous development:

  • Voltage clamp investigation of drug effects on transmembrane ion currents by manual patch-clamp method

Isolated cardiomyocyte model for essential information on the cardiac electrophysiologic effects and safety of compounds.

Available species: rabbit, guinea pig, rat, dog.

 

  • Cardiac action potential by conventional microelectrode technique

QT prolongation with continuous action potential parameters, e.g. duration, amplitude, resting potential, etc.

Available species: rabbit, guinea pig, dog.
Different heart muscle preparations: papillary muscle, Purkinje-fiber, atrial muscle, etc.

 

  • Voltage clamp investigation of drug effects on transmembrane ion currents by automated patch-clamp method

Automated planar patch-clamp method on genetically modified mammalian cell lines for voltage- and ligand-gated ion channels as well as temperature-activated channels in gigaseal quality.

 

  • Cardiac electrophysiology animal models

Wide range of ex vivo and in vivo cardiac electrophysiology models, e.g. chronic atrial fibrillation model, etc.