Publications

Major publications of pharmahungary:

2016

Rajtik T, Carnicka S, Szobi A, Giricz Z, O-Uchi J, Hassova V, Svec P, Ferdinandy P, Ravingerova T, Adameova A.
Oxidative activation of CaMKIIδ in acute myocardial ischemia/reperfusion injury: A role of angiotensin AT1 receptor-NOX2 signaling axis.
Eur J Pharmacol. 2016 Jan 15;771:114-22. doi: 10.1016/j.ejphar.2015.12.024. Epub 2015 Dec 13.

Di Lisa F, Giorgio M, Ferdinandy P, Schulz R.
New aspects of p66Shc in ischemia reperfusion injury and cardiovascular diseases.
Br J Pharmacol. 2016 Mar 15. doi: 10.1111/bph.13478. [Epub ahead of print]

Madonna R, Van Laake LW, Davidson SM, Engel FB, Hausenloy DJ, Lecour S, Leor J, Perrino C, Schulz R, Ytrehus K, Landmesser U, Mummery CL, Janssens S, Willerson J, Eschenhagen T, Ferdinandy P, Sluijter JP.
Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure.
Eur Heart J. 2016 Apr 7. pii: ehw113. [Epub ahead of print] Review.

Sárközy M, Szűcs G, Fekete V, Pipicz M, Éder K, Gáspár R, Sója A, Pipis J, Ferdinandy P, Csonka C, Csont T.
Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats.
Cardiovasc Diabetol. 2016 Aug 5;15(1):110.

Brockhoff B, Schreckenberg R, Forst S, Heger J, Bencsik P, Kiss K, Ferdinandy P, Schulz R, Schlüter KD.
Effect of nitric oxide deficiency on the pulmonary PTHrP system.
J Cell Mol Med. 2016 Aug 31.

Kiss K, Csonka C, Pálóczi J, Pipis J, Görbe A, Kocsis GF, Murlasits Z, Sárközy M, Szűcs G, Holmes CP, Pan Y, Bhandari A, Csont T, Shamloo M, Woodburn KW, Ferdinandy P, Bencsik P.
Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats.
Pharmacol Res. 2016 Aug 10;113(Pt A):62-70.

2015

Schreckenberg R, Weber P, Cabrera-Fuentes HA, Steinert I, Preissner KT, Bencsik P, Sárközy M, Csonka C, Ferdinandy P, Schulz R, Schlüter KD.
Mechanism and consequences of the shift in cardiac arginine metabolism following ischaemia and reperfusion in rats.
Thromb Haemost. 2015 Mar;113(3):482-93

Baán JA, Varga ZV, Leszek P, Kuśmierczyk M, Baranyai T, Dux L, Ferdinandy P, Braun T, Mendler L.
Myostatin and IGF-I signaling in end-stage human heart failure: a qRT-PCR study.
J Transl Med. 2015 Jan 16;13:1.

Csont T, Murlasits Z, Ménesi D, Kelemen JZ, Bencsik P, Pipicz M, Fekete V, Zvara Á, Puskás LG, Ferdinandy P.
Tissue-specific Gene Expression in Rat Hearts and Aortas in a Model of Vascular Nitrate Tolerance.
J Cardiovasc Pharmacol. 2015 May;65(5):485-93

Kirca M, Kleinbongard P, Soetkamp D, Heger J, Csonka C, Ferdinandy P, Schulz R.
Interaction between connexin 43 and nitric oxide synthase in mice heart mitochondria.
J Cell Mol Med. 2015 Apr;19(4):815-25.

Varga ZV, Giricz Z, Bencsik P, Madonna R, Gyöngyösi M, Schulz R, Mayr M, Thum T, Puskás LG, Ferdinandy P.
Functional genomics of cardioprotection by ischemic conditioning and the influence of comorbid conditions: implications in target identification.
Curr Drug Targets. 2015 Apr 27.

Bencsik P, Sasi V, Kiss K, Kupai K, Kolossváry M, Maurovich-Horvat P, Csont T, Ungi I, Merkely B, Ferdinandy P.
Serum lipids and cardiac function correlate with nitrotyrosine and MMP activity in coronary artery disease patients.
Eur J Clin Invest. 2015 May 5.

Madonna R, Cadeddu C, Deidda M, Giricz Z, Madeddu C, Mele D, Monte I, Novo G, Pagliaro P, Pepe A, Spallarossa P, Tocchetti CG, Varga ZV, Zito C, Geng YJ, Mercuro G, Ferdinandy P.
Cardioprotection by gene therapy: A review paper on behalf of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology.
Int J Cardiol. 2015 Jul 15;191:203-210.

Schreckenberg R, da Costa Rebelo M, Deten A, Weber M, Rohrbach S, Pipicz M, Csonka C, Ferdinandy P, Schulz R, Schlüter KD.
Specific Mechanisms underlying Right Heart Failure: The missing Upregulation of Superoxide Dismutase-2 and its decisive Role in Antioxidative Defense.
Antioxid Redox Signal. 2015 May 15.

Schulz R, Görge PM, Görbe A, Ferdinandy P, Lampe PD, Leybaert L.
Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection.
Pharmacol Ther. 2015 Jun 11. pii: S0163-7258(15)00120-5.

Sárközy M, Szűcs G, Pipicz M, Zvara Á, Éder K, Fekete V, Szűcs C, Bárkányi J, Csonka C, Puskás LG, Kónya C, Ferdinandy P, Csont T.
The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats.
Cardiovasc Diabetol. 2015 Jun 28;14:85. doi: 10.1186/s12933-015-0248-6.

Görbe A, Eder A, Varga ZV, Pálóczi J, Hansen A, Ferdinandy P, Eschenhagen T.
Protection by the NO-Donor SNAP and BNP against Hypoxia/Reoxygenation in Rat Engineered Heart Tissue.
PLoS One. 2015 Jul 6;10(7):e0132186. doi: 10.1371/journal.pone.0132186. eCollection 2015.

Madonna R, Petrov L, Teberino MA, Manzoli L, Karam JP, Renna FV, Ferdinandy P, Montero-Menei CN, Ylä-Herttuala S, De Caterina R.
Transplantation of adipose tissue mesenchymal cells conjugated with VEGF-releasing microcarriers promotes repair in murine myocardial infarction.
Cardiovasc Res. 2015 Oct 1;108(1):39-49. doi: 10.1093/cvr/cvv197. Epub 2015 Jul 17.

Varga ZV, Ferdinandy P, Liaudet L, Pacher P.
Drug-induced mitochondrial dysfunction and cardiotoxicity.
Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1453-67. doi: 10.1152/ajpheart.00554.2015. Epub 2015 Sep 18. Review.

Baranyai T, Nagy CT, Koncsos G, Onódi Z, Károlyi-Szabó M, Makkos A, Varga ZV, Ferdinandy P, Giricz Z.
Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning.
Cardiovasc Diabetol. 2015 Nov 18;14:151. doi: 10.1186/s12933-015-0313-1.

Baranyai T, Herczeg K, Onódi Z, Voszka I, Módos K, Marton N, Nagy G, Mäger I, Wood MJ, El Andaloussi S, Pálinkás Z, Kumar V, Nagy P, Kittel Á, Buzás EI, Ferdinandy P, Giricz Z.
Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods.
PLoS One. 2015 Dec 21;10(12):e0145686. doi: 10.1371/journal.pone.0145686. eCollection 2015.

2014

Rassaf T, Ferdinandy P, Schulz R.
Nitrite in Organ Protection.
Br J Pharmacol. 2014 Jan;171(1):1-11.

Csont T, Sárközy M, Sz Cs G, Sz Cs C, Bárkányi J, Bencsik P, Gáspár R, Földesi I, Csonka C, Kónya C, Ferdinandy P.
Effect of a multivitamin preparation supplemented with phytosterol on serum lipids and infarct size in rats fed with normal and high cholesterol diet.
Lipids Health Dis. 2013 Sep 25;12(1):138.

Görbe A, Varga ZV, Pálóczi J, Rungarunlert S, Klincumhom N, Pirity MK, Madonna R, Eschenhagen T, Dinnyés A, Csont T, Ferdinandy P.
Cytoprotection by the NO-Donor SNAP Against Ischemia/Reoxygenation Injury in Mouse Embryonic Stem Cell-Derived Cardiomyocytes.
Mol Biotechnol. 2014 Mar;56(3):258-64.

Csonka C, Kupai K, Bencsik P, Görbe A, Pálóczi J, Zvara A, Puskas LG, Csont T, Ferdinandy P.
Cholesterol-enriched diet inhibits cardioprotection by ATP-cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive potassium channel activators cromakalim and diazoxide.
Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H405-13.

Kadomatsu K, Bencsik P, Görbe A, Csonka C, Sakamoto K, Kishida S, Ferdinandy P.
Therapeutic Potential of Midkine in Cardiovascular Diseases.
Br J Pharmacol. 2014 Feb;171(4):936-44.

Bencsik P, Pálóczi J, Kocsis GF, Pipis J, Belecz I, Varga ZV, Csonka C, Görbe A, Csont T, Ferdinandy P.
Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective.
Pharmacol Res. 2014 Feb;80:36-42.

Csonka C, Szucs G, Varga-Orvos Z, Bencsik P, Csont T, Zvara Á, Puskás LG, Ferdinandy P.
Ischemic postconditioning alters the gene expression pattern of the ischemic heart.
Exp Biol Med (Maywood). 2014 Feb;239(2):141-50.

Giricz Z, Varga ZV, Baranyai T, Sipos P, Pálóczi K, Kittel Á, Buzás EI, Ferdinandy P.
Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles.
J Mol Cell Cardiol. 2014 Mar;68:75-8.

Varga ZV, Zvara A, Faragó N, Kocsis GF, Pipicz M, Gáspár R, Bencsik P, Görbe A, Csonka C, Puskas LG, Thum T, Csont T, Ferdinandy P.
MicroRNAs associated with ischemia/reperfusion injury and cardioprotection by ischemic pre- and postconditioning: ProtectomiRs.
Am J Physiol Heart Circ Physiol. 2014 May 23.

Andreadou I, Iliodromitis EK, Rassaf T, Schulz R, Papapetropoulos A, Ferdinandy P.
The role of gasotransmitters NO, H2 S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning.
Br J Pharmacol. 2014 Jun 12.

Csonka C, Páli T, Bencsik P, Görbe A, Ferdinandy P, Csont T.
Measurement of NO in biological samples.
Br J Pharmacol. 2014 Jul 2

Madonna R, Geng YJ, Shelat H, Ferdinandy P, De Caterina R.
High glucose-induced hyperosmolarity impacts proliferation, cytoskeleton remodeling and migration of human induced pluripotent stem cells via aquaporin-1.
Biochim Biophys Acta. 2014 Nov;1842(11):2266-75.

Sárközy M, Fekete V, Szűcs G, Török S, Szűcs C, Bárkányi J, Varga ZV, Földesi I, Csonka C, Kónya C, Csont T, Ferdinandy P.
Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference.
BMC Endocr Disord. 2014 Aug 26;14:72.

Ferdinandy P, Hausenloy DJ, Heusch G, Baxter GF, Schulz R.
Interaction of Risk Factors, Comorbidities, and Comedications with Ischemia/Reperfusion Injury and Cardioprotection by Preconditioning, Postconditioning, and Remote Conditioning.
Pharmacol Rev. 2014 Oct;66(4):1142-1174.

Pechánová O, Varga Z, Cebová M, Giricz Z, Pacher P, Ferdinandy P.
Cardiac Nitric Oxide Signalling in Metabolic Syndrome.
Br J Pharmacol. 2015 Mar;172(6):1415-33

Lecour S, Bøtker HE, Condorelli G, Davidson SM, Garcia-Dorado D, Engel FB, Ferdinandy P, Heusch G, Madonna R, Ovize M, Ruiz-Meana M, Schulz R, Sluijter JP, Van Laake LW, Yellon DM, Hausenloy DJ.
ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies.
Cardiovasc Res. 2014 Dec 1;104(3):399-411.

Madonna R, Ferdinandy P, De Caterina R, Willerson JT, Marian AJ.
Recent developments in cardiovascular stem cells.
Circ Res. 2014 Dec 5;115(12):e71-8

2013

Monostori P, Kocsis GF, Okrös Z, Bencsik P, Czétényi O, Kiss Z, Gellén B, Bereczki C, Ocsovszki I, Pipis J, Pálóczi J, Sárközy M, Török S, Varga IS, Kiss I, Fodor E, Csont T, Ferdinandy P, Túri S.
Different administration schedules of darbepoetin alfa affect oxidized and reduced glutathione levels to a similar extent in 5/6 nephrectomized rats.
Clin Exp Nephrol. 2013 Aug;17(4):569-74.

Sárközy M, Zvara A, Gyémánt N, Fekete V, Kocsis GF, Pipis J, Szűcs G, Csonka C, Puskás LG, Ferdinandy P, Csont T.
Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats.
Cardiovasc Diabetol. 2013 Jan 15;12:16.

Hausenloy DJ, Erik Bøtker H, Condorelli G, Ferdinandy P, Garcia-Dorado D, Heusch G, Lecour S, van Laake LW, Madonna R, Ruiz-Meana M, Schulz R, Sluijter JP, Yellon DM, Ovize M.
Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology.
Cardiovasc Res. 2013 Apr 1;98(1):7-27.

Hill C, Würfel A, Heger J, Meyering B, Schlüter KD, Weber M, Ferdinandy P, Aronheim A, Schulz R, Euler G.
Inhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction.
Cardiovasc Res. 2013 Jul 1;99(1):121-8.

Madonna R, Görbe A, Ferdinandy P, De Caterina R.
Glucose Metabolism, Hyperosmotic Stress, and Reprogramming of Somatic Cells.
Mol Biotechnol. 2013 Oct;55(2):169-78.

Fekete V, Murlasits Z, Aypar E, Bencsik P, Sárközy M, Szénási G, Ferdinandy P, Csont T.
Myocardial postconditioning is lost in vascular nitrate tolerance.
J Cardiovasc Pharmacol. 2013 Sep;62(3):298-303.

Szűcs G, Murlasits Z, Török S, Kocsis GF, Pálóczi J, Görbe A, Csont T, Csonka C, Ferdinandy P.
Cardioprotection by farnesol: role of the mevalonate pathway.
Cardiovasc Drugs Ther. 2013 Aug;27(4):269-77.

Varga ZV, Kupai K, Szűcs G, Gáspár R, Pálóczi J, Faragó N, Zvara A, Puskás LG, Rázga Z, Tiszlavicz L, Bencsik P, Görbe A, Csonka C, Ferdinandy P, Csont T.
MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart.
J Mol Cell Cardiol. 2013 Sep;62:111-21.

2012

Kocsis GF, Sárközy M, Bencsik P, Pipicz M, Varga ZV, Pálóczi J, Csonka C, Ferdinandy P, Csont T.
Preconditioning protects the heart in a prolonged uremic condition.
Am J Physiol Heart Circ Physiol. 303(10):H1229-36 (2012)

2011

Görbe A, Varga ZV, Kupai K, Bencsik P, Kocsis GF, Csont T, Boengler K, Schulz
R, Ferdinandy P.
Cholesterol diet leads to attenuation of ischemic preconditioning-induced cardiac protection: the role of connexin 43.
Am J Physiol Heart Circ Physiol. 300:H1907-13 (2011)

Szucs G, Bester DJ, Kupai K, Csont T, Csonka C, Esterhuyse AJ, Ferdinandy P, Van Rooyen J.
Dietary red palm oil supplementation decreases infarct size in cholesterol fed rats.
Lipids Health Dis. 10:103 (2011)

2010

Csont T, Görbe A, Bereczki E, Szunyog A, Aypar E, Tóth ME, Varga ZV, Csonka C, Fülöp F, Sántha M, Ferdinandy P.
Biglycan protects cardiomyocytes against hypoxia/reoxygenation injury: Role of nitric oxide.
J Mol Cell Cardiol. 48:649-652 (2010)

Kupai K, Szucs G, Cseh S, Hajdu I, Csonka C, Csont T, Ferdinandy P.
Matrix metalloproteinase activity assays: Importance of zymography.
J Pharmacol Toxicol Methods. 61:205-209 (2010)

Csonka C, Kupai K, Kocsis GF, Novák G, Fekete V, Bencsik P, Csont T, Ferdinandy P.
Measurement of myocardial infarct size in preclinical studies.
J Pharmacol Toxicol Methods. 61:163-170 (2010)

Gorbe A, Giricz Z, Szunyog A, Csont T, Burley DS, Baxter GF, Ferdinandy P.
Role of cGMP-PKG signaling in the protection of neonatal rat cardiac myocytes subjected to simulated ischemia/reoxygenation.
Basic Res Cardiol. 105:643-650 (2010).

Ovize M, Baxter GF, Di Lisa F, Ferdinandy P, Garcia-Dorado D, Hausenloy DJ, Heusch G, Vinten-Johansen J, Yellon DM, Schulz R.
Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology.
Cardiovasc Res. 87:406-423 (2010).

Dormán G, Cseh S, Hajdú I, Barna L, Kónya D, Kupai K, Kovács L, Ferdinandy P.
Matrix metalloproteinase inhibitors: a critical appraisal of design principles and proposed therapeutic utility.
Drugs. 70:949-964 (2010)

Bencsik P, Kupai K, Giricz Z, Görbe A, Pipis J, Murlasits Z, Kocsis GF, Varga-Orvos Z, Puskás LG, Csonka C, Csont T, Ferdinandy P.
Role of iNOS and peroxynitrite-matrix metalloproteinase-2 signaling in myocardial late preconditioning in rats.
Am J Physiol Heart Circ Physiol. 299:H512-518 (2010)

2009

Kupai K, Csonka C, Fekete V, Odendaal L, van Rooyen J, Marais de W, Csont T, Ferdinandy P.
Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitrite.
Am J Physiol Heart Circ Physiol. 297:H1729-35 (2009)

2008

Kocsis GF, Pipis J, Fekete V, Kovacs-Simon A, Odendaal L, Molnar E, Giricz Z, Janaky T, van Rooyen J, Csont T, Ferdinandy P.
Lovastatin interferes with the infarct size-limiting effect of ischemic preconditioning and postconditioning in rat hearts.
Am J Physiol Heart Circ Physiol 294:H2406-2409 (2008)

Csont T, Ferdinandy P.
Letter regarding article “Biglycan is required for adaptive remodeling after myocardial infarction”.
Circulation 118:e521 (2008)

2007

Bereczki E, Gonda S, Csont T, Korpos E, Zvara A, Ferdinandy P, Santha M.
Overexpression of biglycan in the heart of transgenic mice: an antibody microarray study.
J Proteome Res. 6:854-861(2007)

Papp A, Szommer T, Barna L, Gyimesi G, Ferdinandy P, Spadoni C, Darvas F, Fujita T, Ürge L, Dormán G.
Enhanced hit-to-lead process using bioanalogous lead evolution and chemogenomics: application in designing selective matrix metalloprotease inhibitors.
Expert Opin Drug Discov 2:707-723 (2007)

Csont T, Bereczki E, Bencsik P, Fodor G, Gorbe A, Zvara A, Csonka C, Puskas LG, Santha M, Ferdinandy P.
Hypercholesterolemia increases myocardial oxidative and nitrosative stress thereby leading to cardiac dysfunction in apoB-100 transgenic mice.
Cardiovasc Res. 76:100-109 (2007)

Dormán G, Kocsis-Szommer K, Spadoni C, Ferdinandy P.
MMP inhibitors in cardiac diseases: an update.
Recent Patents Cardiovasc Drug Discov 2:186-194 (2007)

Ferdinandy P, Schulz R, Baxter GF.
Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning and postconditioning.
Pharmacol Rev 59:418-458 (2007)

2006

Giricz Z, Lalu MM, Csonka C, Bencsik P, Schulz R, Ferdinandy P.
Hyperlipidemia attenuates the infarct size-limiting effect of ischemic preconditioning: role of matrix metalloproteinase-2 inhibition.
J Pharmacol Exp Ther 316:154-61(2006)

Konya C, Ferdinandy P.
Vitamin C: new role of the old vitamin in the cardiovascular system.
Br J Pharmacol 147:125-127 (2006)

Turan N, Csonka C, Csont T, Giricz Z, Fodor G, Bencsik P, Gyongyosi M, Cakici I, Ferdinandy P.
The role of peroxynitrite in chemical preconditioning with 3-nitropropionic acid in rat hearts.
Cardiovasc Res 70:384-390 (2006)

Ferdinandy P.
Peroxynitrite: just an oxidative/nitrosative stressor or a physiological regulator as well?
Br J Pharmacol 148:1-3 (2006)

2005

Ungi I, Ungi T, Ruzsa Z, Nagy E, Zimmermann Z, Csont T, Ferdinandy P.
Hypercholesterolemia attenuates the anti-ischemic effect of preconditioning during coronary angioplasty.
Chest 128:1623-1628 (2005)