Preclinical r&d services

• Our innovative R&D solutions (InnoRD™) reduce the time of your development as we develop the best preclinical models for your needs.
• Complex animal models of cardiovascular (e.g. infarction, heart failure, stroke) and metabolic diseases (e.g. diabetes, hyperlipidemia, atherosclerosis, obesity, aging) for proof-of-concept studies.

• We design custom models for your needs.
• Special risk sharing opportunities available.

EXAMPLES OF OUR RESEARCH SERVICES IN COMPLEX IN VIVO AND EX VIVO MODELS OF VARIOUS DISEASES, ASK FOR FURTHER DETAILS:

• Testing cardioprotective compounds on acute and chronic coronary occlusion-induced myocardial ischemia/reperfusion, myocardial infarction, preconditioning, and postconditioning.
• Testing compounds for heart failure induced by chronic coronary occlusion-induced infarction, or cardiotoxic agents.
• Testing cardioprotective compounds in organ storage models.
• Testing vascular functions in hyperlipidemia/atherosclerosis and nitrate-tolerance models.

• Evaluation of antidiabetic compounds in type 1 and type 2 diabetic models (STZ, Goto-Kakizaki, Zucker Diabetic Fatty, etc).
• Evaluation of compounds acting on the nitric oxide-cGMP system and peroxynitrite formation, e.g. peroxynitrite scavengers.
• Testing antiplatelet compounds in platelet aggregation systems.
• Testing antioxidant agents in cardiovascular and metabolic disease models.
• Evaluation of cardiac heat-shock protein (HSP) inducers. Evaluation of matrix metalloproteinase (MMP) inhibitors.